49ers vs Bears Week 1 Picks and Predictions: New Bears Era Gets Rough Start

Two of the NFL’s most storied franchises will collide in Week 1 as the San Francisco 49ers visit the Chicago Bears at Soldier Field this Sunday. 

The 49ers fought the eventual Super Bowl Champion Los Angeles Rams valiantly in the 2021 NFC Championship Game, but ultimately lost 20-17. The Bears limped to a 6-11 record in quarterback Justin Fields’ rookie campaign, and head coach Matt Nagy and GM Ryan Pace answered for it with their jobs. 

Can Chicago secure its first win in the Matt Eberflus-Ryan Poles era, or will San Francisco’s newly-anointed starting quarterback, Trey Lance, have his day in the sun? Find out in our free NFL picks and predictions for 49ers vs Bears on Sunday, September 11.

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